| QB |
| Deshaun Watson | Hou | 27.00 | Passing 292 Yds, 1 TD, 2 INT Rushing 44 Yds, 2 TD |
| RB1 |
| Nick Chubb | Cle | 14.00 | Rushing 106 Yds Receiving 1 Rec, 11 Yds |
| RB2 |
| Leonard Fournette | Jax | 9.00 | Rushing 50 Yds Receiving 3 Rec, 13 Yds |
| WR1 |
| Amari Cooper | Dal | 20.00 | Receiving 6 Rec, 83 Yds, 1 TD |
| WR2 |
| Tyler Boyd | Cin | 12.00 | Rushing 7 Yds Receiving 5 Rec, 75 Yds |
| TE |
| Jack Doyle | Ind | 4.00 | |
| FLEX |
| Calvin Ridley | Atl | 18.00 | Receiving 5 Rec, 76 Yds, 1 TD |
| D |
| 49ers D/ST | SF | -2.00 | |
| K |
| Justin Tucker | Bal | 6.00 | |
| Ben1 |
| Marvin Jones Jr. | Det | 6.00 | |
| Ben2 |
| Matt Breida | SF | 6.00 | Rushing 54 Yds Receiving 1 Rec, 4 Yds |
| Ben3 |
| Greg Olsen O | Sea | 0.00 | |
| Ben4 |
| Sammy Watkins | KC | 9.00 | |
| Ben5 |
| Carlos Hyde | Hou | 9.00 | Rushing 73 Yds Receiving 2 Rec, 5 Yds |
| Ben6 |
| Jimmy Garoppolo | SF | 36.00 | Passing 349 Yds, 4 TD, 1 INT Rushing 1 Yds |
| Ben7 |
| Cole Beasley | Buf | 14.00 | Receiving 4 Rec, 29 Yds, 1 TD, 1 2PT |