| QB |
| C.J. Stroud | Hou | 23.38 | Passing 192 Yds, 3 TD, 1 INT Rushing 7 Yds |
| RB1 |
| Breece Hall | NYJ | 23.90 | Rushing 113 Yds Receiving 5 Rec, 56 Yds |
| RB2 |
| Saquon Barkley | Phi | 7.40 | Rushing 47 Yds Receiving 2 Rec, 7 Yds |
| WR1 |
| Keenan Allen | Chi | 21.10 | Receiving 5 Rec, 41 Yds, 2 TD |
| WR2 |
| Darnell Mooney | Atl | 6.80 | |
| TE |
| Sam LaPorta | Det | 12.20 | Receiving 1 Rec, 52 Yds, 1 TD |
| FLEX |
| D'Andre Swift | Chi | 21.90 | Rushing 91 Yds, 1 TD Receiving 4 Rec, 28 Yds |
| D |
| Colts D/ST | Ind | 4.00 | |
| K |
| Brandon Aubrey | Dal | 12.00 | |
| Ben1 |
| Michael Pittman Jr. Q | Ind | 12.50 | Receiving 3 Rec, 35 Yds, 1 TD |
| Ben2 |
| Malik Nabers O | NYG | 0.00 | |
| Ben3 |
| Jaxon Smith-Njigba | Sea | 10.30 | |
| Ben4 |
| T.J. Hockenson | Min | 0.00 | |
| Ben5 |
| Allen Lazard | NYJ | 23.40 | Receiving 6 Rec, 114 Yds, 1 TD |
| Ben6 |
| Kareem Hunt | KC | 0.00 | |
| Ben7 |
| Tucker Kraft | GB | 3.50 | Rushing 2 Yds Receiving 2 Rec, 13 Yds |
| IR |
| Nick Chubb O | Cle | 0.00 | |