| QB |
| Jalen Hurts | Phi | 17.32 | Passing 158 Yds, 1 TD Rushing 20 Yds, 1 TD, 1 Fum |
| RB1 |
| Derrick Henry | Bal | 37.90 | Rushing 199 Yds, 1 TD Receiving 3 Rec, 10 Yds, 1 TD |
| RB2 |
| Tony Pollard | Ten | 18.80 | Rushing 88 Yds, 1 TD Receiving 2 Rec, 20 Yds |
| WR1 |
| Justin Jefferson | Min | 20.50 | Receiving 6 Rec, 85 Yds, 1 TD |
| WR2 |
| Drake London | Atl | 12.40 | |
| TE |
| George Kittle | SF | 14.50 | Receiving 4 Rec, 45 Yds, 1 TD |
| FLEX |
| David Montgomery | Det | 15.00 | Rushing 40 Yds, 1 TD Receiving 1 Rec, 40 Yds |
| D |
| 49ers D/ST | SF | 24.00 | Defense 6 Sack, 1 INT, 2 Fum Rec, 1 TD, 7‑13 PA |
| K |
| Harrison Butker | KC | 4.00 | |
| Ben1 |
| Brandon Aiyuk | SF | 6.80 | |
| Ben2 |
| Xavier Worthy | KC | 16.30 | Receiving 3 Rec, 73 Yds, 1 TD |
| Ben3 |
| Ladd McConkey | LAC | 17.70 | Receiving 5 Rec, 67 Yds, 1 TD |
| Ben4 |
| Gus Edwards | LAC | 1.90 | |
| Ben5 |
| Adam Thielen | Car | 0.00 | |
| Ben6 |
| Quentin Johnston | LAC | 2.30 | Rushing 4 Yds Receiving 1 Rec, 9 Yds |
| Ben7 |
| Pat Freiermuth | Pit | 16.70 | Receiving 5 Rec, 57 Yds, 1 TD |