| QB |
| Jalen Hurts | Phi | 24.82 | Passing 183 Yds, 1 TD, 1 INT Rushing 85 Yds, 1 TD |
| RB1 |
| Derrick Henry | Bal | 16.60 | Rushing 84 Yds, 1 TD Receiving 1 Rec, 12 Yds |
| RB2 |
| David Montgomery | Det | 17.00 | Rushing 35 Yds, 1 TD Receiving 4 Rec, 35 Yds |
| WR1 |
| Justin Jefferson | Min | 23.30 | Receiving 4 Rec, 133 Yds, 1 TD |
| WR2 |
| Drake London | Atl | 17.40 | Receiving 6 Rec, 54 Yds, 1 TD |
| TE |
| George Kittle | SF | 20.60 | Receiving 7 Rec, 76 Yds, 1 TD |
| FLEX |
| Xavier Worthy | KC | 4.20 | Rushing 5 Yds Receiving 2 Rec, 17 Yds |
| D |
| 49ers D/ST | SF | 10.00 | Defense 4 Sack, 1 INT, 1 Fum Rec |
| K |
| Harrison Butker | KC | 10.00 | |
| Ben1 |
| Brandon Aiyuk | SF | 8.30 | |
| Ben2 |
| Tony Pollard | Ten | 15.20 | Rushing 62 Yds Receiving 5 Rec, 40 Yds |
| Ben3 |
| Ladd McConkey | LAC | 4.60 | |
| Ben4 |
| Gus Edwards | LAC | 5.90 | |
| Ben5 |
| Curtis Samuel | Buf | 1.30 | |
| Ben6 |
| Adam Thielen | Car | 4.00 | |
| Ben7 |
| Quentin Johnston | LAC | 22.10 | Receiving 5 Rec, 51 Yds, 2 TD |