| QB |
| Jared Goff | Det | 20.32 | Passing 213 Yds, 2 TD Rushing -2 Yds |
| RB1 |
| Christian McCaffrey | SF | 22.30 | Rushing 93 Yds, 1 TD Receiving 3 Rec, 40 Yds |
| RB2 |
| Tony Pollard | Ten | 17.30 | Rushing 68 Yds, 1 TD Receiving 3 Rec, 15 Yds |
| WR1 |
| Jaylen Waddle | Mia | 10.20 | |
| WR2 |
| Amon-Ra St. Brown | Det | 12.90 | Receiving 2 Rec, 49 Yds, 1 TD |
| TE |
| Trey McBride Q | Ari | 22.90 | Receiving 8 Rec, 89 Yds, 1 TD |
| FLEX |
| Zack Moss | Cin | 7.70 | Rushing 51 Yds Receiving 2 Rec, 6 Yds |
| D |
| Browns D/ST | Cle | -1.00 | |
| K |
| Brandon Aubrey | Dal | 15.00 | |
| Ben1 |
| DJ Moore | Chi | 0.00 | |
| Ben2 |
| Tyler Lockett | Sea | 9.70 | |
| Ben3 |
| Jordan Addison | Min | 0.00 | |
| Ben4 |
| De'Von Achane | Mia | 25.30 | Rushing 73 Yds, 2 TD Receiving 3 Rec, 30 Yds |
| Ben5 |
| Zach Charbonnet | Sea | 16.90 | Rushing 60 Yds, 1 TD Receiving 1 Rec, 39 Yds |
| Ben6 |
| Elijah Mitchell | SF | 1.30 | |
| Ben7 |
| Lamar Jackson | Bal | 0.00 | |
| IR |
| Dallas Goedert D | Phi | 0.00 | |