| QB |
| Lamar Jackson | Bal | 15.76 | Passing 174 Yds, 1 TD, 1 INT Rushing 58 Yds |
| RB1 |
| Christian McCaffrey | SF | 23.40 | Rushing 54 Yds, 1 TD Receiving 7 Rec, 50 Yds |
| RB2 |
| Nick Chubb | Cle | 27.40 | |
| WR1 |
| Justin Jefferson | Min | 30.32 | Passing 23 Yds Receiving 12 Rec, 154 Yds, 1 2PT |
| WR2 |
| Amari Cooper | Cle | 20.60 | Receiving 7 Rec, 76 Yds, 1 TD |
| TE |
| Tyler Higbee | LAR | 11.60 | |
| FLEX |
| DK Metcalf | Sea | 16.80 | Rushing 1 Fum Receiving 5 Rec, 88 Yds, 1 TD |
| D |
| 49ers D/ST | SF | 16.00 | Defense 6 Sack, 1 INT, 1 TD, 14‑17 PA |
| K |
| Tyler Bass | Buf | 7.00 | |
| Ben1 |
| T.J. Hockenson | Min | 1.60 | |
| Ben2 |
| Chase Edmonds | TB | 0.10 | |
| Ben3 |
| Allen Lazard | NYJ | 13.50 | Receiving 4 Rec, 35 Yds, 1 TD |
| Ben4 |
| Garrett Wilson | NYJ | 5.70 | |
| Ben5 |
| Brian Robinson Jr. | Was | 2.20 | |
| Ben6 |
| Alexander Mattison | Min | 7.00 | Rushing 19 Yds Receiving 3 Rec, 21 Yds |
| Ben7 |
| J.D. McKissic | FA | 8.70 | |